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Concomitance or consequence? Stevens-Johnson syndrome in COVID-19: A case report

Carmen Manciuc1, Georgiana Alexandra Lacatusu2, Andrei Vata1

  • 1Department of Infectious Diseases, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.

Experimental and Therapeutic Medicine
|March 9, 2022
PubMed

Insights

A rare case of Stevens-Johnson syndrome (SJS) occurred in a COVID-19 patient in Romania. This association highlights the potential for severe skin reactions and emphasizes the need for prompt recognition and treatment.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Virology

Background:

  • The novel coronavirus (SARS-CoV-2) pandemic presents significant medical, economic, and social challenges.
  • Cutaneous manifestations of COVID-19 can be diverse and may indicate infection.
  • Stevens-Johnson syndrome (SJS) is a severe mucocutaneous reaction often triggered by medications or infections.

Observation:

  • A 77-year-old male with SARS-CoV-2 infection presented with a generalized maculopapular-erythematous eruption, crusting, and desquamation.
  • The patient also experienced low back pain, headache, and orbital pain.
  • Clinical suspicion of Stevens-Johnson syndrome (SJS) was raised based on the observed dermatological symptoms.

Findings:

  • This case represents the first documented instance of SJS in a patient diagnosed with SARS-CoV-2 infection in Romania.
  • The patient received treatment for SJS as recommended by dermatologists.
  • The presentation raises questions about whether SJS is a direct cutaneous manifestation of COVID-19 or a coincidental immune response.

Implications:

  • The co-occurrence of SJS and COVID-19 can lead to fatal outcomes if not promptly diagnosed and managed.
  • This case underscores the importance of considering severe cutaneous reactions in patients with COVID-19.
  • Further research is needed to elucidate the relationship between SARS-CoV-2 infection and immune-mediated dermatological conditions like SJS.

Keywords:
SARS CoV-2Stevens-Johnson syndromecutaneous manifestationemergencypandemic

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