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Updated: Oct 1, 2025

Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
[Adipocytokines: modern definition, classification and physiological role]
T N Markova1, N K Mishchenko2, D V Petina3
1City Clinical Hospital №52; Moscow State University of Medicine and Dentistry named after A.I. Evdokimov.
Abstract:
Adipose tissue is an endocrine organ which produces a large number of secretory bioactive substances also known as adipocytokines affecting directly insulin resistance (IR), glucose and lipid metabolism, angiogenesis and inflammation. The studies show a close connection between the imbalance of adipocytokines formed as a result of excessive deposit of adipose tissue in the course of the development of type 2 diabetes mellitus and cardiovascular diseases. In the present review, we summarize current data on the effect of the adipocytokines on the liver, skeletal muscles, adipose tissue, endothelial cells and inflammatory processes, as well as attempt to define the term «adipocytokines» and classify adipocytokines according to their influence on metabolic processes and pro-inflammatory status. Some of adipocytokines (adiponectin, omentin, leptin, resistin, tumor necrosis factor-α and interleukin-6) are divided into two groups: adipocytokines reducing IR, and adipocytokines increasing IR.
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