Pyridazine N-Oxides as Photoactivatable Surrogates for Reactive Oxygen Species
Vitalii S Basistyi1, James H Frederich1
1Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States.
Abstract:
A method for the photoinduced evolution of atomic oxygen from pyridazine N-oxides was developed. This underexplored oxygen allotrope mediates arene C-H oxidation within complex, polyfunctional molecules. A water-soluble pyridazine N-oxide was also developed and shown to promote photoinduced DNA cleavage in aqueous solution. Taken together, these studies highlight the utility of pyridazine N-oxides as photoactivatable O(3P) precursors for applications in organic synthesis and chemical biology.
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