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Updated: Oct 1, 2025

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
Published on: January 26, 2024
Standing Watch: Immune Activation and Failure in Melanoma Sentinel Lymph Nodes
1The Ronald O. Perelman Department of Dermatology, Department of Pathology, Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, New York.
Abstract:
An unbiased approach to map the sentinel lymph node landscape reveals progressive immune dysfunction associated with micrometastasis in patients with stage I-III cutaneous melanoma. Evidence of tumor-induced lymph node dysfunction may motivate new hypotheses for neoadjuvant therapy with potential to reinvigorate endogenous antitumor immunity. See related article by Yaddanapudi et al., p. 2069.
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