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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

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Published on: April 11, 2019

Monocytes asphyxiate germinal centers.

Yuke He¹, Carola G Vinuesa²

¹Centre for Personalised Immunology (CACPI), Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, 200001, China.

|March 9, 2022

Summary

This summary is machine-generated.

Salmonella bacteria disrupt immune germinal centers, impairing antibody production. This study reveals how Salmonella recruits specific monocytes to germinal centers, hindering immune cell adaptation and function.

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Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

Area of Science:

Immunology
Microbiology
Cell Biology

Background:

Some pathogens, like Salmonella, disrupt germinal centers, leading to low-affinity antibodies.
The precise mechanisms microbes use to alter immune responses remain unclear.

Purpose of the Study:

To investigate how Salmonella influences germinal center responses.
To uncover the mechanism by which Salmonella impairs immune adaptation.

Main Methods:

Investigated the interaction between Salmonella and germinal centers.
Analyzed the recruitment of Sca-1+ monocytes to germinal centers.

Main Results:

Salmonella actively recruits Sca-1+ monocytes to germinal centers.
This recruitment impairs the metabolic adaptation of immune cells within germinal centers.

Conclusions:

Salmonella employs a mechanism involving Sca-1+ monocyte recruitment to disrupt germinal center function.
This disruption leads to suboptimal antibody responses, aiding pathogen survival.