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A high-resolution view of intra-tumoral B cell immunity
1GV20 Therapeutics, Cambridge, MA, USA.
Immunity
|March 9, 2022
Abstract:
In this issue of Immunity, Meylan et al. (2022) uses spatial transcriptomics to examine B cell immunity within intratumoral tertiary lymphoid structures (TLSs). They find that B cells expand and mature into plasma cells (PCs) within the TLS, migrate along fibroblastic tracks to tumor beds, and produce IgG antibodies that target cancer cells.

