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Related Experiment Video

Updated: Oct 1, 2025

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Bubble-based microrobots enable digital assembly of heterogeneous microtissue modules.

Zhixing Ge^1,2,3, Liguo Dai^1,2,3, Junhua Zhao^1,4,5

¹State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, People's Republic of China.

|March 9, 2022

Summary

This summary is machine-generated.

Researchers developed a new digital method to assemble microscale multicellular tissue modules. This technique uses light projection and microrobots to create functional tissue structures, mimicking natural tissue properties.

Keywords:

bubble microrobots digital micromirror device (DMD)high-throughput fabrication reconfigurable assembly

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Last Updated: Oct 1, 2025

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Patterning of Microorganisms and Microparticles through Sequential Capillarity-assisted Assembly

Published on: November 4, 2021

Area of Science:

Biomaterials Engineering
Tissue Engineering
Microfabrication

Background:

Heterogeneous micromechanical environments are crucial for tissue functions like regeneration and angiogenesis.
Manufacturing and assembling microscale multicellular heterogeneous tissue modules in vitro remains a significant challenge.

Purpose of the Study:

To propose a novel digital method for assembling heterogeneous microtissue modules.
To demonstrate the fabrication and control of multicellular microstructures with tunable mechanical properties.

Main Methods:

Utilized digital micromirror device-based optical projection lithography.
Employed bubble-based microrobots for manipulation in a liquid environment.
Fabricated multicellular microstructures using a microfluidic chip with multiple inlets.

Main Results:

Successfully fabricated multicellular microstructures by increasing microfluidic chip inlets.
Demonstrated fine-tuning of Young's modulus for entire modules and specific regions via exposure time.
Constructed a bionic peritoneum with surface morphology, mechanical properties, and internal structure similar to native tissue.
Showcased the system's ability to control module posture and simulate peritoneal metastasis.

Conclusions:

The developed digital assembly system offers a novel approach for creating complex microtissue modules.
The system allows for precise control over mechanical properties, mimicking native tissue.
This technology holds potential for applications in tissue engineering, regenerative medicine, and disease modeling.