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Updated: Oct 1, 2025
Video-oculography in Mice
Published on: July 19, 2012
Is Video-Oculography a Predictive Test for Myasthenia Gravis with Ocular Symptoms?
Tuba Cerrahoglu Sirin1, Zerrin Karaaslan2, Burcu N Arkali2
1Department of Neurology and Clinical Neurophysiology, Istanbul University, Istanbul Faculty of Medicine; Department of Neurology, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.
Background And Objective:
The aim of this study was to evaluate the contribution of extraocular muscle function testing with video-oculography (VOG), which is a noninvasive and easily applicable method of recording eye movement with digital cameras, to the diagnosis of myasthenia gravis (MG) in patients without any clinical eye movement abnormalities.
Methods And Materials:
The study included 18 patients prediagnosed with ocular MG: MG Group (N = 7) with abnormal, and non-MG Group (N = 11) with normal single-fiber electromyography. Control group included 50 healthy volunteers. Ocular movements were recorded with the EyeSeeCam VOG device.
Results:
The inward latency of the 10° horizontal saccade and the downward latency of the 10° vertical saccade were significantly delayed; and the downward amplitude of the 10° vertical saccade was significantly lower in the MG group. Receiver operating characteristic curve analyses showed high specificity values for the discrimination of MG patients.
Conclusions:
This study supports the usefulness of the VOG device in revealing subclinical extraocular muscle involvement in MG.
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