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Updated: Oct 1, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Malignant Melanoma of the Brainstem: A Unicorn Not a Popcorn
Rajesh Meena1, Ramesh S Doddamani1, Surya Sri K Gour1
1Department of Neurosurgery, All India Institute of Medical Sciences, New-Delhi, India.
Background:
Primary intracranial malignant melanomas (PIMMs) are uncommon lesions of the central nervous system. Brainstem involvement is of rare occurrence.
Methods And Material:
A 33-year-old male presented with the chief complaints of progressively increasing headache, visual disturbances, and diplopia from the last 6 months. Magnetic resonance imaging (MRI) showed a well-defined lesion in the midbrain appearing heterogeneously hyperintense on T1WI and containing mixed hyperintense and hypointense areas on T2WI. Multiple areas of SWI blooming, suggestive of hemorrhage, were seen within the lesion.
Conclusion:
Brainstem malignant melanoma can masquerade cavernoma as seen in our case. Therefore, malignant melanomas should be considered in the differential diagnosis of brainstem lesions that presents with bleed.
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