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Pregabalin Induced Maculopapular Eruption in an Elderly Male
Sumit Jaiswal1, Sankha Shubhra Chakrabarti1, Tulika Rai1
1Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Current Drug Safety
|March 10, 2022
Summary
Pregabalin, a medication for neuropathic pain and epilepsy, can cause maculopapular rash. This skin reaction in older adults resolved with drug withdrawal and conservative care.
Area of Science:
- Pharmacology
- Neurology
- Dermatology
Background:
- Pregabalin is a widely prescribed medication for neuropathic pain and epilepsy.
- Its mechanism involves blocking α2δ subunits of calcium channels.
- It is often preferred due to a favorable safety profile compared to other treatments.
Observation:
- A case study identified a maculopapular rash in an elderly male patient.
- The rash was directly linked to pregabalin use.
- Symptoms resolved upon discontinuation of the medication.
Findings:
- Pregabalin can induce maculopapular skin rashes.
- Literature review indicates this is a recognized, though uncommon, adverse effect.
- Management involves drug withdrawal and symptomatic treatment.
Implications:
- Clinicians should be aware of potential skin reactions to pregabalin, especially in geriatric patients.
- Early recognition and management can prevent complications.
- This highlights the importance of monitoring for adverse drug reactions.
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