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Related Experiment Video

Updated: Oct 1, 2025

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Resurgent and delayed malaria.

Brian Greenwood¹, Issaka Zongo², Alassane Dicko³

¹Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK. brian.greenwood@lshtm.ac.uk.

Malaria Journal

|March 10, 2022

Summary

Malaria control interventions can lead to a delayed increase in malaria risk in children after the program ends. This "delayed malaria" phenomenon requires strategies to mitigate its impact on public health.

Keywords:

Delayed malaria Immunity Malaria Rebound malaria Resurgent malaria

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Area of Science:

Tropical Medicine
Infectious Diseases
Epidemiology

Background:

Repeated exposure to malaria in endemic areas confers immunity.
Reduced exposure due to control measures can diminish this immunity.
Withdrawal of interventions can lead to increased malaria risk, termed 'rebound malaria'.

Purpose of the Study:

To discuss the phenomenon of 'delayed malaria'.
To differentiate 'delayed malaria' from 'rebound malaria'.
To suggest measures for mitigating the impact of delayed malaria.

Main Methods:

Review of evidence on delayed malaria occurrence.
Analysis of malaria control intervention impacts.
Discussion of epidemiological patterns in malaria transmission.

Main Results:

Malaria control efforts focused on children may not reduce overall burden but delay it.
Interventions like insecticide-treated nets, chemoprevention, and vaccines may lead to delayed malaria.
The risk period for delayed malaria is concentrated after intervention cessation.

Conclusions:

Delayed malaria is a distinct concern from rebound malaria.
Sustained malaria control strategies are crucial.
Proactive measures are needed to address the impact of delayed malaria in vulnerable populations.