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Published on: March 6, 2019
Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a
A Rosala-Hallas1, Ashley P Jones1, Paula R Williamson2
1Liverpool Clinical Trials Centre, University of Liverpool, Liverpool, Merseyside, UK.
Objectives:
The objective of this study was to develop a core outcome set (COS) for use in future clinical trials in bronchiolitis. We wanted to find out which outcomes are important to healthcare professionals (HCPs) and to parents and which outcomes should be prioritised for use in future clinical trials.
Design And Setting:
The study used a systematic review, workshops and interviews, a Delphi survey and a final consensus workshop.
Results:
Thirteen parents and 45 HCPs took part in 5 workshops; 15 other parents were also separately interviewed. Fifty-six items were identified from the systematic review, workshops and interviews. Rounds one and two of the Delphi survey involved 299 and 194 participants, respectively. Sixteen outcomes met the criteria for inclusion within the COS. The consensus meeting was attended by 10 participants, with representation from all three stakeholder groups. Nine outcomes were added, totalling 25 outcomes to be included in the COS.
Conclusion:
We have developed the first parent and HCP consensus on a COS for bronchiolitis in a hospital setting. The use of this COS will ensure outcomes in future bronchiolitis trials are important and relevant, and will enable the trial results to be compared and combined.
Trial Registration Number:
ISRCTN75766048.
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