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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Area of Science:

  • Environmental Health Sciences
  • Aging Biology
  • Neuroscience

Background:

  • Genetics alone does not determine neurological aging or disease susceptibility.
  • Environmental health sciences and aging biology are increasingly intersecting.
  • A 2020 workshop highlighted the need to integrate aging and environmental health research.

Purpose of the Study:

  • To review overlaps and gaps in current knowledge at the intersection of aging biology and environmental health.
  • To identify essential research initiatives and policy development opportunities.
  • To explore how technological advances can bridge disciplinary gaps.

Main Methods:

  • Scoping review of existing literature.
  • Overview of aging biology and biomarkers.
  • Examples of synergy between aging and environmental health sciences.

Main Results:

  • Technological advances like multi-omics and exposomic research offer new integration opportunities.
  • Cumulative risk frameworks acknowledge life-course exposures and stressors.
  • New biomarkers grounded in aging biology can improve understanding of population vulnerability.

Conclusions:

  • Interdisciplinary research is critical for understanding how environmental exposures alter biological aging.
  • Focus areas include exposomics, microbiome, toxicant mixtures, and social determinants of health.
  • Integrated research can improve policy, reduce health disparities, and enhance quality of life for older adults.