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Role of Mitophagy in the Pathogenesis of Stroke: From Mechanism to Therapy
Wei-Jie Zhong1, Xiao-Sheng Yang1, Han Zhou1
1Department of Neurosurgery, Ninth People Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Abstract:
Mitochondria can supply adenosine triphosphate (ATP) to the tissue, which can regulate metabolism during the pathologic process and is also involved in the pathophysiology of neuronal injury after stroke. Recent studies have suggested that selective autophagy could play important roles in the pathophysiological process of stroke, especially mitophagy. It is usually mediated by the PINK1/Parkin-independent pathway or PINK1/Parkin-dependent pathway. Moreover, mitophagy may be a potential target in the therapy of stroke because the control of mitophagy is neuroprotective in stroke in vitro and in vivo. In this review, we briefly summarize recent researches in mitophagy, introduce the role of mitophagy in the pathogenesis of stroke, then highlight the strategies targeting mitophagy in the treatment of stroke, and finally propose several issues in the treatment of stroke by targeting mitophagy.
Insights
Mitophagy, a cellular process, plays a key role in stroke pathophysiology. Targeting mitophagy offers a promising neuroprotective strategy for stroke treatment.
Area of Science:
- Neuroscience
- Cellular Biology
- Pathophysiology
Background:
- Mitochondria generate ATP, regulating metabolism and neuronal injury in stroke.
- Selective autophagy, particularly mitophagy, is increasingly recognized in stroke pathogenesis.
- Mitophagy involves PINK1/Parkin-dependent and -independent pathways.
Purpose of the Study:
- To review recent research on mitophagy.
- To introduce the role of mitophagy in stroke pathogenesis.
- To highlight therapeutic strategies targeting mitophagy for stroke treatment.
Main Methods:
- Literature review of mitophagy research.
- Analysis of mitophagy's role in stroke.
- Identification of therapeutic targets.
Main Results:
- Mitophagy is implicated in the pathophysiology of neuronal injury post-stroke.
- Control of mitophagy demonstrates neuroprotective effects in stroke models.
- PINK1/Parkin pathways are key mediators of mitophagy.
Conclusions:
- Mitophagy is a critical factor in stroke development and progression.
- Targeting mitophagy presents a potential therapeutic avenue for stroke.
- Further research is needed to address challenges in mitophagy-based stroke therapies.
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