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Diffuse Large B Cell Lymphoma with Cutaneous and Gastrointestinal Involvement.

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  • 1Gastroenterology Department, Thingangyun General Hospital, Yangon, Myanmar.

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Diffuse large B cell lymphoma (DLBCL) can affect multiple organs, including the skin and gastrointestinal tract. This case highlights DLBCL presenting with skin nodules and obstructive jaundice, emphasizing the need for comprehensive diagnosis.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Dermatology

Background:

  • Diffuse large B cell lymphoma (DLBCL) is a common non-Hodgkin's lymphoma subtype.
  • Extranodal DLBCL frequently involves the GI tract, head/neck, and skin.
  • Early diagnosis of extranodal DLBCL is crucial for effective treatment.

Observation:

  • A patient presented with cutaneous nodules and gastrointestinal bleeding.
  • Imaging revealed a pancreatic tumor causing biliary obstruction and a gastric ulcer.
  • Histopathology confirmed DLBCL in skin and stomach, despite negative gastric LCA.

Findings:

  • The patient had disseminated DLBCL with simultaneous involvement of skin, pancreas, and stomach.
  • Clinical presentation included obstructive jaundice and upper GI bleeding.
  • Radiological and histopathological findings were key to diagnosis.

Implications:

  • This case underscores the importance of considering disseminated DLBCL in patients with unexplained skin and GI symptoms.
  • Physicians should be vigilant for multifocal extranodal involvement in DLBCL.
  • Accurate diagnosis of extranodal DLBCL aids in timely and appropriate therapeutic interventions.