Synergistic Anti-tumor Effect of Dichloroacetate and Ivermectin
Tatsuaki Ishiguro1, Ryumei H Ishiguro1, Miyu Ishiguro1
1Tumor Biology, Kamui Medical Co. Ltd., Tokyo, JPN.
Abstract:
We formerly reported that the combination of dichloroacetate, omeprazole, and tamoxifen blocked cancer progression by reducing lactic acid production and inducing superoxide production. Recently, ivermectin, a well-known anti-parasite drug, was reported to share the same mechanisms with them and have anti-tumor activity. Here, we present three patients in whom the combination of dichloroacetate, omeprazole (plus tamoxifen), and ivermectin dramatically relieved the symptoms accompanying cancer and sarcoma progression.
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