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Interstitial Granulomatous Drug Reaction: A Case Report
Raghad T Aldibane1, Khalid Al Hawsawi1
1Dermatology Department, King Abdulaziz Hospital, Makkah, SAU.
Cureus
|March 10, 2022
Summary
Interstitial granulomatous drug reaction (IGDR) is a rare skin condition. This case report details a 55-year-old female diagnosed with IGDR, noting its asymptomatic nature and localized presentation.
Area of Science:
- Dermatology
- Pathology
Background:
- Interstitial granulomatous drug reaction (IGDR) is a rare inflammatory skin condition with an unclear cause.
- This report focuses on a specific patient case to illustrate IGDR presentation and management.
Observation:
- A 55-year-old female with diabetes and hypertension presented with a year-long, asymptomatic, erythematous annular skin lesion on her left breast.
- Physical examination revealed a sharply demarcated, non-scaly patch.
- Skin biopsy demonstrated epidermal atrophy and a significant histiocytic infiltrate in the dermis.
Findings:
- The patient was diagnosed with Interstitial granulomatous drug reaction (IGDR).
- Histopathology confirmed a diffuse histiocytic infiltrate consistent with IGDR.
Implications:
- The case highlights that IGDR can be asymptomatic and localized.
- Management decisions considered the patient's stable chronic conditions and the benign nature of the lesion.
- No medication changes were made due to the lesion's mildness and lack of complications.
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