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Updated: Sep 30, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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2,2,2-Trifluoroacetaldehyde O-(Aryl)oxime: A Precursor of Trifluoroacetonitrile
Bo Lin1,2, Yunfei Yao2, Yangjie Huang1
1Fujian Engineering Research Center of New Chinese Lacquer Material, Ocean College, Minjiang University, Fuzhou 350108, China.
Abstract:
The preparation of 2,2,2-trifluoroacetaldehyde O-(aryl)oxime, a previously inaccessible precursor of trifluoroacetonitrile, via reaction of hydroxylamine and trifluoroacetaldehyde hydrate is reported. This precursor released CF3CN in quantitative yield under mildly basic conditions. The precursor was successfully used in the synthesis of trifluoromethylated oxadiazoles. The facile, cost-effective, scalable, and recyclable procedure makes these trifluoroacetonitrile precursors generally applicable.
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