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Related Experiment Video

Updated: Sep 30, 2025

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

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Technologies for measuring red blood cell deformability.

Kerryn Matthews1,2, Erik S Lamoureux1,2, Marie-Eve Myrand-Lapierre1

  • 1Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC, V6T 1Z4, Canada. hongma@mech.ubc.ca.

Lab on a Chip
|March 10, 2022
PubMed
Summary
This summary is machine-generated.

Measuring red blood cell (RBC) deformability is crucial for disease diagnosis. Microfluidic technologies offer superior sensitivity and throughput compared to traditional methods for assessing RBC health.

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Area of Science:

  • Biomedical Engineering
  • Hematology
  • Cellular Mechanics

Background:

  • Human red blood cells (RBCs) must deform to navigate narrow capillaries for oxygen delivery.
  • Loss of RBC deformability is linked to various diseases and can serve as a biomarker.
  • Accurate measurement of RBC deformability requires high sensitivity and throughput.

Purpose of the Study:

  • To review traditional and microfluidic techniques for measuring RBC deformability.
  • To compare the capabilities, sensitivity, throughput, and robustness of these methods.
  • To discuss the application of these techniques in biomedical research and clinical settings.

Main Methods:

  • Overview of established methods: micropipette aspiration, ektacytometry, and cell transit analyzer.
  • Detailed examination of microfluidic approaches leveraging precise fluid control at the cellular scale.
  • Comparative analysis of bulk and single-cell measurement techniques.

Main Results:

  • Microfluidic technologies have advanced significantly in the last decade.
  • These newer methods outperform traditional techniques in sensitivity, throughput, consistency, and ease of use.
  • Microfluidics enable precise control of forces and fluid dynamics at the microscale.

Conclusions:

  • Microfluidic tools are transitioning from research to practical applications for biomedical discoveries.
  • RBC deformability measurements can aid in diagnosing diseases like malaria and hemoglobinopathies.
  • These techniques are valuable for monitoring RBC quality during blood storage and transfusion.