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Updated: Sep 30, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells
Sang-Hyun Park1, Hyoje Jung1, Yujun Kim1
1Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea. injae@yonsei.ac.kr.
Abstract:
We describe a fluorogenic probe BocLys(Ac)-AB-FC targeting both histone deacetylases (HDACs) and cathepsin L, which are overexpressed in spatially separated subcellular organelles of cancer cells. The results show that this fluorogenic probe can be used for selective cancer cell imaging without interference arising from normal cells.
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