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Updated: Sep 30, 2025
07:32
An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
Published on: December 3, 2020
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OPTN/SRTR 2020 Annual Data Report: Intestine
S P Horslen1,2, J M Smith1,3, T Weaver1
1Scientific Registry of Transplant Recipients, Hennepin Healthcare Resear- ch Institute, Minneapolis, MN.
Summary
Intestine transplant activity has declined over the past decade, despite recent small increases. While 1-year graft survival improves, long-term survival and overall transplant rates remain a concern for patients needing intestinal transplants.
Area of Science:
- Organ transplantation
- Gastroenterology
- Immunology
Background:
- Intestine transplantation is a complex procedure with evolving trends.
- Understanding recent activity and outcomes is crucial for patient care and research.
Purpose of the Study:
- To analyze trends in intestine transplant waitlist, activity, and patient survival over the last decade.
- To evaluate graft survival rates and immunosuppression strategies in intestine transplant recipients.
Main Methods:
- Retrospective analysis of intestine transplant data from 2019-2020 and historical trends.
- Examination of waitlist dynamics, transplant rates, mortality, graft survival, and immunosuppression protocols.
Main Results:
- A decade-long trend of decreasing intestine transplant activity, despite minor increases in 2019-2020.
- Declining waitlist mortality for pediatric patients; stable for adults.
- Continued improvement in 1-year graft survival, with no significant change in 3- and 5-year survival.
- Tacrolimus-based immunosuppression is favored post-induction.
- Identical 5-year patient survival for isolated intestine and liver-inclusive allografts.
Conclusions:
- Despite improvements in short-term graft survival and pediatric waitlist mortality, overall intestine transplant activity has declined over the last decade.
- Long-term graft survival remains a challenge, necessitating further research into optimized immunosuppression and surgical techniques.
- Patient survival is comparable for different types of intestinal allografts, suggesting the viability of these complex procedures.
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