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Related Experiment Video

Updated: Jun 30, 2026

Novel Apparatus and Method for Drug Reinforcement
07:32

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Published on: August 20, 2010

Can initial experiences with drugs predict future drug abuse risks?

Neil B Varshneya1, Kelly E Dunn1, Caitlyn J Grubb1

  • 1Behavioral Pharmacology Research Unit.

Experimental and Clinical Psychopharmacology
|March 10, 2022
PubMed
Summary
This summary is machine-generated.

First-time drug experiences shape future use. Initial feelings of relief from alcohol or energy from cannabis predict higher substance use disorder severity and demand, suggesting early subjective effects are key indicators.

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Area of Science:

  • Neuroscience and Behavioral Psychology
  • Addiction Research
  • Substance Use Disorder Etiology

Background:

  • Early drug experiences significantly influence motivations for continued substance use.
  • Understanding the link between initial subjective effects and subsequent substance use disorder (SUD) severity is crucial for prevention and treatment.
  • The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) provides criteria for classifying alcohol use disorder (AUD) and cannabis use disorder (CUD).

Purpose of the Study:

  • To investigate the relationship between subjective effects experienced during first-time alcohol or cannabis use and the severity of AUD or CUD.
  • To examine how initial subjective drug experiences predict behavioral economic demand for alcohol or cannabis.
  • To identify specific early subjective effects that may serve as predictors for the development and severity of SUDs.

Main Methods:

  • Analyzed self-reports of initial subjective effects from 463 participants whose first substance use was alcohol or cannabis.
  • Employed ordinal logistic regression to assess the association between initial subjective effects and DSM-5 AUD/CUD severity.
  • Utilized a hypothetical purchase task to measure behavioral economic demand, assessing consumption as a function of price.

Main Results:

  • Experiencing 'relief' during first alcohol use was significantly associated with increased DSM-5 AUD severity (OR = 2.52, p = .0005).
  • Experiencing 'energetic' effects during first cannabis use was significantly associated with increased DSM-5 CUD severity (OR = 2.31, p = .0004).
  • Individuals reporting 'relief' from initial alcohol use exhibited significantly higher hypothetical purchase demand (Pmax) compared to those who did not (p = .0237).

Conclusions:

  • Initial subjective effects of alcohol and cannabis consumption can predict the development and severity of substance misuse and related disorders.
  • The findings support the hypothesis that early positive or arousing subjective experiences may predispose individuals to problematic substance use.
  • Subjective effects during first use are critical factors in understanding SUDs and may inform targeted early intervention strategies.