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Updated: Sep 30, 2025

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

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Future of kidney imaging: Functional magnetic resonance imaging and kidney disease progression

Sidar Copur1, Furkan Yavuz1, Alan A Sag2

  • 1Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.

European Journal of Clinical Investigation
|March 10, 2022
PubMed
Abstract

Insights

Functional magnetic resonance imaging (fMRI) shows promise in predicting chronic kidney disease (CKD) progression. Blood oxygenation level-dependent MRI and diffusion-weighted MRI correlate with estimated glomerular filtration rate changes, aiding CKD management.

Area of Science:

  • Nephrology
  • Radiology
  • Medical Imaging

Background:

  • Chronic kidney disease (CKD) is a growing global health concern with increasing mortality.
  • Current methods lack established approaches for accurately predicting CKD progression.
  • Functional magnetic resonance imaging (fMRI) offers novel techniques for assessing kidney function.

Purpose of the Study:

  • To review the role of fMRI techniques in evaluating kidney function in native and transplanted kidneys.
  • To assess the potential of fMRI methods in predicting CKD progression.
  • To analyze the working mechanisms, advantages, and limitations of various fMRI modalities for renal applications.

Main Methods:

  • A systematic literature review was conducted across major databases (Embase, Cochrane, PubMed/Medline, Web of Science).
  • Studies focusing on fMRI assessment of kidney function and CKD progression prediction were included.
  • Analysis of three studies investigating fMRI's role in kidney function was performed.

Main Results:

  • Blood oxygenation level-dependent MRI (BOLD-MRI) signal showed an inverse correlation with annual estimated glomerular filtration rate (eGFR) change.
  • Diffusion-weighted MRI (DWI-MRI) apparent diffusion coefficient (ADC) values correlated with annual eGFR decline.
  • fMRI modalities demonstrated potential for detailed kidney function assessment.

Conclusions:

  • fMRI techniques, including BOLD-MRI and DWI-MRI, can provide valuable insights into CKD progression.
  • These advanced MRI methods, currently used in other systems, can be adapted for enhanced renal assessment.
  • Clinicians should prepare to interpret kidney MRIs for improved patient management and prediction of CKD outcomes.
Keywords:
arterial spin labelling MRIblood oxygenation level-dependent MRIchronic kidney diseasediffusion-tensor MRIdiffusion-weighted MRIeGFRfunctional MRIglomerular filtration ratekidney functions

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