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Updated: Sep 30, 2025
09:53
An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
Published on: August 25, 2017
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Clonality, Mutation and Kaposi Sarcoma: A Systematic Review
Blanca Iciar Indave Ruiz1, Subasri Armon1, Reiko Watanabe1
1International Agency for Research on Cancer (IARC), World Health Organization, 69372 Lyon, France.
Cancers
|March 10, 2022
Summary
Kaposi sarcoma (KS) may produce tumors, but evidence is insufficient to classify it as a clonal neoplasm. Further research is needed to determine if KS is a virus-driven lesion or a true sarcoma.
Area of Science:
- Oncology
- Virology
- Genetics
Background:
- Kaposi sarcoma (KS) etiology is debated, particularly its classification as a neoplasm.
- Uncertainty exists regarding KS regression upon removal of Human Herpesvirus 8 (HHV-8) stimulus and reduced immunosuppression.
Purpose of the Study:
- To evaluate the available evidence on somatic mutations and clonality in KS.
- To determine if KS exhibits characteristics of a neoplasm.
Main Methods:
- Systematic literature search of Medline and Web of Science up to September 2020.
- Independent study selection and data extraction by two researchers.
- Methodological quality appraisal using an adapted QUADAS-2 tool.
Main Results:
- Twenty publications were eligible for qualitative synthesis from 3077 identified records.
- Studies reported on clonality (5), mutations (10), and chromosomal aberrations (5) in KS.
- High risk of bias and considerable heterogeneity in results were noted across studies.
Conclusions:
- KS exhibits tumor formation, but its nature as a clonal neoplasm remains undetermined.
- Current knowledge is insufficient to definitively classify KS as a sarcoma versus a reactive, virus-driven lesion.
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