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Related Experiment Videos

Fine needle aspiration minibiopsies.

W H Kern, H Haber

    Acta Cytologica
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Cell buttons from fine needle aspirates are diagnostically valuable, aiding tumor classification. This simple method preserves tissue architecture for advanced studies, improving diagnostic accuracy.

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    Area of Science:

    • Cytopathology
    • Surgical Pathology
    • Oncology

    Background:

    • Fine needle aspiration (FNA) is a common diagnostic tool.
    • Cell button preparation is an established technique for FNA specimens.
    • Assessing the diagnostic utility of cell buttons is crucial for optimizing pathology workflows.

    Purpose of the Study:

    • To evaluate the diagnostic contribution of cell buttons prepared from fine needle aspirates.
    • To determine the rate at which cell buttons provide diagnoses not achievable by smears alone.
    • To highlight the suitability of cell button specimens for advanced histochemical and electron microscopic analyses.

    Main Methods:

    • A retrospective review of 1,375 fine needle aspirates over five and a half years.
    • Preparation of cell buttons from selected FNA specimens.

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  • Comparison of diagnoses obtained from cell buttons versus conventional smears.
  • Assessment of tissue architecture preservation in cell button specimens.

    • Main Results:

    • Cell buttons were prepared from 393 (29%) of the 1,375 FNA cases.
    • 237 cell buttons (60.3% of prepared buttons) were diagnostically helpful when used with smears.
    • In 103 cases (7% of all cases), cell buttons enabled definitive tumor diagnosis or classification.
    • Preserved tissue architecture in cell buttons was suitable for special studies.

    Conclusions:

    • Cell button preparation from FNA is a valuable adjunct to cytological smears.
    • This technique significantly enhances diagnostic capabilities, particularly for tumor classification.
    • The preserved architecture makes cell buttons ideal for ancillary studies, supporting wider adoption.