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Oral Acid Load Down-Regulates Fibroblast Growth Factor 23
Angela Vidal1,2, Carmen Pineda1,2, Ana I Raya1,2
1Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, 14014 Cordoba, Spain.
Nutrients
|March 10, 2022
Summary
Increased dietary acid load lowers Fibroblast Growth Factor 23 (FGF23) levels in rats, regardless of kidney function. This effect is linked to reduced parathyroid hormone (PTH) levels.
Area of Science:
- Nephrology
- Endocrinology
- Metabolic Research
Background:
- Dietary acid load negatively impacts health, especially with compromised kidney function.
- Fibroblast Growth Factor 23 (FGF23) is a hormone elevated in renal failure, but its relation to metabolic acidosis is unclear.
Purpose of the Study:
- To investigate the effect of dietary acid load on circulating FGF23 levels in rats with varying renal function.
Main Methods:
- Rats with normal and reduced renal mass (1/2 Nx, 5/6 Nx) were given oral NH4Cl for one month.
- Plasma FGF23 and parathyroid hormone (PTH) levels were measured and compared to control groups.
Main Results:
- Acid intake consistently decreased plasma FGF23 in all groups (intact, 1/2 Nx, 5/6 Nx) compared to controls.
- Metabolic acidosis also reduced plasma PTH levels across all groups.
- FGF23 showed a strong positive correlation with PTH (r=0.877).
Conclusions:
- Plasma FGF23 concentrations are decreased in rats with metabolic acidosis due to increased acid intake, irrespective of renal function.
- The effect of metabolic acidosis on FGF23 is linked to a simultaneous decrease in PTH.
