Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mast cell degranulation in nasal polyps.

T Takasaka, Y Kaku, K Hozawa

    Acta Oto-Laryngologica. Supplementum
    |January 1, 1986
    PubMed
    Summary

    Mast cell degranulation is crucial in nasal polyp formation, particularly in aspirin intolerance and allergic rhinitis cases. This process may involve mechanisms beyond IgE, requiring further immunological investigation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Erythema punctatum Higuchi: reconsidering its relationship with adrenergic urticaria and eruptive pseudoangiomatosis.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2021
    Same author

    Sterile abscesses possibly stem from acantholytic folliculitis in comedonal Darier disease: a case report.

    The British journal of dermatology·2021
    Same author

    Successful treatment of severe blepharitis in a patient with atopic dermatitis by topical delgocitinib.

    Clinical and experimental dermatology·2021
    Same author

    Atypical blue naevus of the labium minus confirmed by whole-exome sequencing.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same author

    Anti-laminin γ1 pemphigoid with IgE autoantibodies.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same author

    Pruritic skin involvement of necrotizing sarcoid granulomatosis: a case report.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2019

    Area of Science:

    • Immunology
    • Pathology
    • Rhinology

    Background:

    • Nasal polyps are inflammatory growths in the nasal cavity.
    • Understanding the cellular mechanisms driving polyp formation is essential for effective treatment.

    Purpose of the Study:

    • To investigate the role of mast cell degranulation and inflammatory cell infiltration in nasal polyps.
    • To compare these features across different rhinitis subtypes, including aspirin intolerance.

    Main Methods:

    • Light and electron microscopy were used to examine nasal polyps from 15 patients.
    • Immunohistochemical studies identified inflammatory cell types and immunoglobulin presence.
    • Morphological analysis focused on neutrophil migration and mast cell degranulation.

    Main Results:

    • Nasal polyps showed significant infiltration of neutrophils, eosinophils, plasma cells, mast cells, lymphocytes, and macrophages.
    • Accelerated mast cell degranulation was observed, with higher rates in aspirin intolerance (AA) and allergic rhinitis (NA) compared to chronic rhinosinusitis (CS).
    • While IgE-positive cells were rare, IgG and IgA were frequently detected in all polyp samples.

    Conclusions:

    • Mast cell degranulation appears to be a key factor in nasal polyp development.
    • The mechanism of mast cell degranulation in nasal polyps may not solely be IgE-dependent.
    • Further immunological research is needed to explore alternative pathways involved in nasal polyp pathogenesis.

    Related Experiment Videos