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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Sep 30, 2025

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
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Choroidal Thickness and Primary Open-Angle Glaucoma-A Narrative Review.

Alice Verticchio Vercellin1, Alon Harris1, Ari M Stoner2

  • 1Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Journal of Clinical Medicine
|March 10, 2022
PubMed
Summary

Choroidal thickness (CT) shows potential as a biomarker for glaucoma, but conflicting pilot studies highlight the need for standardized methods and larger trials to confirm its clinical utility in managing this optic neuropathy.

Keywords:
choroidchoroidal thicknessimagingopen-angle glaucomaoptical coherence tomography

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Vascular Biology

Background:

  • The choroid, particularly the choriocapillaris, is crucial for retinal metabolism and vision, supplying essential blood flow to ocular tissues.
  • Choroidal thickness (CT) is proposed as a quantifiable health biomarker for choroidal tissues, analogous to retinal nerve fiber layer thickness.
  • Glaucoma has known vascular contributions, making choroidal health a relevant factor in disease onset and progression.

Purpose of the Study:

  • To review and critically discuss the existing data on choroidal thickness (CT) in relation to glaucoma.
  • To evaluate the potential relevance and limitations of CT as a biomarker in glaucoma disease management.
  • To address the conflicting findings in pilot studies and identify factors complicating the assessment of CT's clinical utility.

Main Methods:

  • Review of available scientific literature and pilot studies investigating choroidal thickness in glaucoma.
  • Discussion of advancements in imaging technologies, such as optical coherence tomography angiography and enhanced depth imaging, for CT assessment.
  • Critical analysis of methodological challenges, including customized analysis, small sample sizes, and heterogeneous patient groups.

Main Results:

  • Pilot studies on choroidal thickness in glaucoma have yielded conflicting results, with some supporting its clinical utility and others against it.
  • The clinical assessment of choroidal tissues has been historically challenging due to the inaccessibility of CT biomarker targets.
  • Advancements in imaging have enabled CT assessment, but its relationship to glaucomatous optic neuropathy requires further robust investigation.

Conclusions:

  • Choroidal thickness (CT) holds potential as a biomarker for glaucoma, but current evidence is conflicting and limited by methodological issues.
  • Standardized analysis methods, larger sample sizes, and well-controlled studies are necessary to establish the definitive clinical relevance of CT in glaucoma management.
  • Further research is required to overcome existing limitations and fully understand the role of choroidal vascularity in glaucomatous optic neuropathy.