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Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
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Related Experiment Video

Updated: Sep 30, 2025

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
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67Cu Production Capabilities: A Mini Review.

Liliana Mou1, Petra Martini2, Gaia Pupillo1

  • 1Legnaro National Laboratories, National Institute for Nuclear Physics, Legnaro, 35020 Padova, Italy.

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|March 10, 2022
PubMed
Summary

Worldwide production of Copper-67 (67Cu) is feasible to meet rising demands for preclinical and clinical theranostic applications. This review details production methods, purification, and quality control for sustainable 67Cu supply.

Keywords:
Cu-67copper radionuclides productionradiopharmaceuticalstheranostics

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Area of Science:

  • Nuclear Medicine
  • Radiochemistry
  • Theranostics

Background:

  • Copper-67 (67Cu) is a promising theranostic radionuclide with increasing demand for personalized therapies.
  • Current global production capacity and feasibility for expanding 67Cu supply require comprehensive assessment.
  • The growing need for 67Cu necessitates evaluation of various production and purification strategies.

Purpose of the Study:

  • To assess the worldwide feasibility of Copper-67 (67Cu) production for expanded preclinical and clinical use.
  • To review and compare different accelerator- and reactor-based production routes for 67Cu.
  • To analyze separation, purification, target recovery, and quality control aspects crucial for sustainable 67Cu supply.

Main Methods:

  • Comprehensive review of existing literature on 67Cu production routes (accelerator and reactor-based).
  • Analysis of nuclear reactions, separation and purification techniques, and target material recovery procedures.
  • Evaluation of radiochemical, chemical, and radionuclidic purity, including 64Cu coproduction.

Main Results:

  • Detailed overview of current 67Cu supply status and its use in non-clinical and clinical studies.
  • Comparison of different production routes regarding efficiency, purity, and economic sustainability.
  • Identification of critical factors for quality control, especially concerning 64Cu coproduction.

Conclusions:

  • Worldwide production of 67Cu is feasible and essential to meet the growing demand for theranostic applications.
  • Optimization of production, purification, and recovery processes is vital for economic sustainability.
  • Future developments in infrastructure and radiopharmaceuticals will further enhance 67Cu's clinical utility.