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Published on: April 10, 2015
A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and
Rosita Cappai1, Alessandra Fantasia1, Guido Crisponi1
1Dipartimento di Scienze della Vita e dell'Ambiente, Università di Cagliari, 09042 Monserrato-Cagliari, Italy.
Abstract:
The increasing biomedical interest in high-stability oxidovanadium(IV) complexes with hydroxypyridinone ligands leads us to investigate the complex formation equilibria of VIVO2+ ion with a tetradentate ligand, named KC21, which contains two 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) moieties, and with the simple bidentate ligand that constitutes the basic unit of KC21, for comparison, named L5. These equilibrium studies were conducted with joined potentiometric-spectrophotometric titrations, and the results were substantiated with EPR measurements at variable pH values. This multi-technique study gave evidence of the formation of an extremely stable 1:1 complex between KC21 and oxidovanadium(IV) at a physiological pH, which could find promising pharmacological applications.
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