Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infection in postoperative patients.

H H Stone

    The American Journal of Medicine
    |July 28, 1986
    PubMed
    Summary

    Surgical infections often involve mixed aerobic and anaerobic bacteria. Effective antibiotic selection, like third-generation cephalosporins, is key for treatment and prevention, but persistent sepsis may require surgical intervention.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Soft tissue infections.

    The American surgeon·2000
    Same author

    Obstructive jaundice due to Coccidioides immitis.

    Gastrointestinal endoscopy·1996
    Same author

    Surgical Infection Society intra-abdominal infection study. Prospective evaluation of management techniques and outcome.

    Archives of surgery (Chicago, Ill. : 1960)·1993
    Same author

    Acute postoperative hypokalemia.

    Current surgery·1990
    Same author

    Pathogenicity of the enterococcus in surgical infections.

    Annals of surgery·1990
    Same author

    Pancreatic denervation for pain relief in chronic alcohol associated pancreatitis.

    The British journal of surgery·1990

    Area of Science:

    • Infectious Diseases
    • Surgical Infections
    • Antimicrobial Therapy

    Background:

    • Surgical infections commonly result from polymicrobial contamination, frequently involving aerobic and anaerobic bacteria.
    • Endogenous sources are the primary origin of these infections, with synergistic interactions between aerobic gram-negative rods and anaerobes posing significant virulence.
    • Sepsis, particularly when stemming from such symbiotic bacterial relationships, presents a major clinical challenge.

    Purpose of the Study:

    • To review the principles of antimicrobial therapy in the management of surgical infections.
    • To highlight the role of specific antibiotic classes, such as third-generation cephalosporins, in treating and preventing these infections.
    • To emphasize the critical importance of appropriate antibiotic selection based on pathogen spectrum, pharmacokinetics, and safety.

    Main Methods:

    • Literature review on the etiology and treatment of surgical infections.
    • Analysis of antibiotic efficacy, focusing on spectrum of activity, half-life, and toxicity.
    • Discussion of treatment strategies for persistent or uncontrolled sepsis.

    Main Results:

    • Antibiotics are effective in treating and preventing surgical infections.
    • Third-generation cephalosporins offer a favorable profile due to broad-spectrum activity, extended half-life, and low toxicity.
    • Failure to control sepsis with antibiotics can precipitate multi-organ system failure.

    Conclusions:

    • Judicious antibiotic selection is paramount for successful surgical infection management.
    • Third-generation cephalosporins represent a valuable therapeutic option.
    • Aggressive surgical intervention is essential for patient survival in cases of refractory sepsis.

    Related Experiment Videos