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Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Related Experiment Video

Updated: Sep 30, 2025

Techniques to Induce and Quantify Cellular Senescence
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Synergistic Anti-Ageing through Senescent Cells Specific Reprogramming.

Rui Chen1, Thomas Skutella1

  • 1Group for Regeneration and Reprogramming, Medical Faculty, Department of Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, 69120 Heidelberg, Germany.

Cells
|March 10, 2022
PubMed
Summary

Partial reprogramming of senescent cells may offer a novel strategy for cellular rejuvenation by creating a beneficial microenvironment. Controlled interventions aim to improve aging, repair damage, and extend healthy lifespan while mitigating risks.

Keywords:
SASPageingp16Ink4ap19Arfp21Waf1/Cip1senescencesenolytics/senostatics

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Area of Science:

  • Gerontology and Cellular Biology
  • Regenerative Medicine
  • Biotechnology

Background:

  • Cellular senescence, a state of irreversible growth arrest, contributes to aging and age-related diseases.
  • The senescence-associated secretory phenotype (SASP) promotes chronic inflammation and tissue dysfunction.
  • Current strategies lack precise control over senescent cell reprogramming, posing risks like tumor formation.

Purpose of the Study:

  • To explore partial reprogramming of senescent cells as a strategy for cellular rejuvenation.
  • To investigate the potential of modulating the senescence-associated secretory phenotype (SASP) for improved aging.
  • To assess the translational value of controlled reprogramming for enhancing healthy lifespan and reducing frailty.

Main Methods:

  • Review of existing literature on cellular senescence and reprogramming.
  • Analysis of partial reprogramming strategies and their impact on the SASP.
  • Discussion of potential clinical translation pathways and associated challenges.

Main Results:

  • Partial reprogramming can induce a rejuvenating secretory phenotype in senescent cells.
  • Controlled partial reprogramming may alleviate age-related inflammation and improve tissue health.
  • The strategy holds promise for enhancing damage repair and promoting longevity.

Conclusions:

  • Partial reprogramming offers a promising avenue for rejuvenation by targeting senescent cells.
  • Careful control is essential to mitigate risks associated with reprogramming, such as oncogenesis and loss of cellular identity.
  • Further research into safe and feasible clinical protocols is critical for translating these advances into therapeutic applications.