Related Experiment Video

Updated: Sep 30, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.8K

Revealing the Roles of MOAP1 in Diseases: A Review

Yanfang Su1, Weixia Wang1, Xianfang Meng1

  • 1Department of Neurobiology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Cells
|March 10, 2022
PubMed

Insights

Modulator of apoptosis protein 1 (MOAP1) is crucial in cancer and neurological disease development. It regulates apoptosis genes like BAX and interacts with microRNAs, offering potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Disease Mechanisms

Background:

  • Modulator of apoptosis protein 1 (MOAP1), also known as MAP1 and PNMA4, is part of the PNMA gene family.
  • MOAP1 interacts with BAX, a key regulator of apoptosis.
  • Its involvement in disease-associated pathways links MOAP1 to various conditions.

Purpose of the Study:

  • To introduce MOAP1 and its biological functions.
  • To review associations between MOAP1 and diseases like cancer, neurological disorders, inflammation, and heart disease.
  • To explore potential mechanisms and future research directions for MOAP1.

Main Methods:

  • Literature review of MOAP1's role in disease.
  • Analysis of MOAP1's interactions with apoptosis regulators (e.g., BAX, RASSF1A).
  • Examination of MOAP1's interaction with disease-associated microRNAs (miRNAs).

Main Results:

  • MOAP1 is implicated in the pathogenesis of cancers and neurological diseases.
  • MOAP1 regulates key apoptosis-related genes (BAX, RASSF1A).
  • MOAP1 interacts with specific miRNAs (miR-25, miR1228) involved in disease.

Conclusions:

  • MOAP1 plays a significant role in cancer and neurological disease progression.
  • Understanding MOAP1's mechanisms, including gene and miRNA interactions, is vital.
  • MOAP1 presents potential as a therapeutic target, particularly in neurodegenerative disorders.
Keywords:
MOAP1apoptosisbiomarkercancerneurodegenerative diseases

More Related Videos

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.8K
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy08:26

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

5.8K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Aquaporins01:25

Aquaporins

Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
5.2K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
6.3K
Microtubule Associated Proteins (MAPs)01:42

Microtubule Associated Proteins (MAPs)

Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
4.7K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
4.1K