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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring
Anna Starzyńska1, Piotr Wychowański2,3, Maciej Nowak4
1Department of Oral Surgery, Medical University of Gdańsk, 7 Dębinki Street, 80-211 Gdańsk, Poland.
Insights
Maternal periodontitis, an inflammatory oral condition, may negatively impact pregnancy outcomes and offspring health. This review explores the links between maternal gum disease and complications like preeclampsia and preterm birth.
Area of Science:
- Oral Health
- Maternal-Fetal Medicine
- Developmental Pediatrics
Background:
- Periodontal disease (PD) is a prevalent inflammatory condition affecting oral health in various age groups.
- Research indicates a significant occurrence of PD among pregnant women.
- As a bacterial-induced inflammatory disease, PD can activate pathways influencing pregnancy progression and outcomes.
Purpose of the Study:
- To investigate the influence of maternal periodontitis on pregnancy complications and offspring's long-term systemic health.
- To analyze the molecular pathways and mechanisms underlying the association between maternal periodontal health and offspring development.
- To address the PICO question regarding the impact of maternal periodontitis versus healthy periodontium on pregnancy and offspring health outcomes.
Main Methods:
- Systematic literature review.
- PICO framework application for research question formulation.
- Analysis of existing research on maternal periodontitis and its effects.
Main Results:
- Evidence suggests maternal periodontitis is linked to adverse pregnancy outcomes, including preeclampsia, preterm delivery, vulvovaginitis, and low birth weight.
- Potential impact of maternal periodontitis on the offspring's epigenome is indicated.
- Maternal periodontitis may lead to health issues in offspring during childhood and adulthood.
Conclusions:
- Maternal periodontitis poses risks to pregnancy course and outcomes.
- Potential for maternal periodontitis to influence offspring epigenetics and long-term health.
- Further research is warranted to elucidate the mechanisms and long-term consequences.
Abstract:
Periodontal disease (PD) is one of the most common oral conditions affecting both youths and adults. There are some research works suggesting a high incidence of PD in pregnant women. As an inflammatory disease of bacterial origin, PD may result in the activation of the pathways affecting the course and the pregnancy outcome. The authors, based on the literature review, try to answer the PICO question: Does maternal periodontitis (exposure) influence the incidence of complications rates in pregnancy and the development of systemic diseases in childhood and adult offspring (outcome) in the humans of any race (population) compared to the offspring of mothers with healthy periodontium (comparison)? The authors try to describe the molecular pathways and mechanisms of these interdependencies. There is some evidence that maternal periodontitis may affect the pregnancy course and outcome, resulting in preeclampsia, preterm delivery, vulvovaginitis and low birth weight. It can be suggested that maternal periodontitis may affect offspring epigenome and result in some health consequences in their adult life.
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