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Updated: Sep 30, 2025

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
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Current Development, Obstacle and Futural Direction of Induced Pluripotent Stem Cell and Mesenchymal Stem Cell

Ming-Cheng Chiang1, Edward Chern1

  • 1niChe Lab for Stem Cell and Regenerative Medicine, Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan.

International Journal of Molecular Sciences
|March 10, 2022
PubMed

Insights

Stem cell therapy offers a promising avenue for treating degenerative retinal diseases, a leading cause of vision loss. Induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) present ethical and practical advantages over traditional sources.

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Degenerative retinal diseases cause significant global vision loss.
  • Traditional stem cell sourcing faces ethical and availability challenges.
  • Induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) offer alternatives.

Purpose of the Study:

  • To review the current applications and advancements in stem cell therapy for retinal diseases.
  • To examine clinical trials and recent research in this field.
  • To discuss limitations and future prospects of stem cell treatments for vision restoration.

Main Methods:

  • Literature review of stem cell therapy for retinal degeneration.
  • Analysis of current clinical trial data.
  • Synthesis of recent research findings on iPSCs and MSCs in ophthalmology.

Main Results:

  • Stem cell therapy is an emerging treatment for vision loss due to retinal diseases.
  • iPSCs and MSCs address ethical concerns and cell sourcing limitations.
  • Ongoing research and clinical trials show potential for regenerative medicine in ophthalmology.

Conclusions:

  • Stem cell therapy, particularly using iPSCs and MSCs, represents a significant advancement in regenerative medicine for retinal diseases.
  • Further research and clinical trials are crucial to overcome existing limitations and optimize treatment outcomes.
  • This approach holds promise for restoring vision and addressing a major global health concern.
Keywords:
induced pluripotent stem cellsmesenchymal stem cellretinal diseasereview article

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