Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

5.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.5K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.2K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.5K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.5K
Embryonic Stem Cells00:57

Embryonic Stem Cells

3.8K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
3.8K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.8K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

5-Methylcytidine RNA Epitranscriptomics in Women's Health and Disease: Mechanisms and Clinical Implications.

Cells·2026
Same author

PCYT1B-Targeting miRNAs as Potential Biomarkers for Placental Diseases.

International journal of molecular sciences·2026
Same author

Multi-omics Approaches for Biomarker Discovery of Uterine Fibroids: A Systematic Review.

Advances in therapy·2026
Same author

Role of extracellular vesicles in fertility preservation before gonadotoxic exposures to the ovaries and testes.

Human reproduction (Oxford, England)·2026
Same author

Molecular Insights into Widespread Pseudouridine RNA Modifications: Implications for Women's Health and Disease.

Biology·2026
Same author

Decoding Bromodomain and Extra-Terminal Domain Protein-Mediated Epigenetic Mechanisms in Human Uterine Fibroids.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Sep 30, 2025

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

14.6K

Stem Cell Therapy: From Idea to Clinical Practice.

Mohammad Mousaei Ghasroldasht1, Jin Seok1, Hang-Soo Park1

  • 1Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.

International Journal of Molecular Sciences
|March 10, 2022
PubMed
Summary
This summary is machine-generated.

This review covers the translation of stem cell therapies from lab research to clinical use, including regulatory guidelines from the FDA and EMA, and summarizes current regenerative medicine trials.

Keywords:
clinical trialmesenchymal stem cellregenerative medicinestem cell therapy

More Related Videos

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

2.1K
Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

9.4K

Related Experiment Videos

Last Updated: Sep 30, 2025

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

14.6K
Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

2.1K
Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

9.4K

Area of Science:

  • Regenerative Medicine
  • Stem Cell Therapy
  • Clinical Translation

Background:

  • Stem cells offer therapeutic potential for various diseases by modulating inflammation, apoptosis, and promoting tissue repair.
  • Preclinical successes have led to numerous clinical trials for stem cell-based treatments.
  • Translating these therapies requires navigating complex regulatory pathways.

Purpose of the Study:

  • To outline the process of translating stem cell products from research to clinical practice.
  • To familiarize readers with regulatory guidelines for clinical trial approval.
  • To review and discuss registered regenerative medicine clinical trials.

Main Methods:

  • Review of regulatory guidelines from the Food and Drug Administration (FDA) and European Medicine Agency (EMA).
  • Analysis and summarization of clinical trial studies registered on Clinicaltrials.gov.
  • Discussion of the challenges and requirements for stem cell product translation.

Main Results:

  • Stem cell therapies hold promise for diseases with limited treatment options.
  • Regulatory bodies like the FDA and EMA provide frameworks for clinical trial approval.
  • A significant number of regenerative medicine trials are documented on Clinicaltrials.gov.

Conclusions:

  • Successful translation of stem cell therapies requires adherence to strict regulatory standards.
  • Understanding regulatory pathways is crucial for advancing regenerative medicine.
  • Clinicaltrials.gov serves as a valuable resource for tracking the progress of regenerative medicine research.