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Metal complexes with first-row transition metals enhance the anti-inflammatory properties of nonsteroidal anti-inflammatory drugs (NSAIDs). This review highlights research on these promising metallodrugs.

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Area of Science:

  • Coordination Chemistry
  • Metallodrugs
  • Pharmacology

Background:

  • The discovery of cisplatin spurred research into coordination chemistry and metallodrugs.
  • First-row transition metal complexes show potential pharmacological properties.
  • Metal complexes can enhance the biological activities of organic drugs.

Purpose of the Study:

  • To review research on coordination compounds of first-row transition metals (copper, cobalt, nickel, manganese, zinc) and NSAIDs.
  • To highlight the enhanced pharmacological properties of these metallodrugs.
  • To focus on promising or effective results in this field.

Main Methods:

  • Review of scientific literature on coordination compounds.
  • Analysis of metal complexes involving first-row transition metals.
  • Focus on complexes with nonsteroidal anti-inflammatory drugs (NSAIDs).

Main Results:

  • Metal complexes can significantly improve the biological activities of NSAIDs.
  • NSAIDs' N and O donor atoms facilitate coordination to metal ions.
  • Complexes of first-row transition metals and NSAIDs exhibit promising anti-inflammatory effects.

Conclusions:

  • Coordination compounds of first-row transition metals and NSAIDs represent a promising area for developing effective metallodrugs.
  • These complexes offer enhanced anti-inflammatory, anticancer, and antimicrobial properties.
  • Further research into these metallodrugs is warranted.