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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Murine Superficial Lymph Node Surgery
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STAT3 Role in T-Cell Memory Formation.

Yaroslav Kaminskiy1, Jan Joseph Melenhorst1

  • 1Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.

International Journal of Molecular Sciences
|March 10, 2022
PubMed
Summary
This summary is machine-generated.

The signal transducer and activator of transcription-3 (STAT3) pathway is vital for creating long-term T-cell memory. This pathway supports robust antitumor immunity and effective recall responses against cancer.

Keywords:
STAT3T-cell differentiationantitumor immunitycellular therapyimmune response

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Area of Science:

  • Immunology
  • Cancer Biology
  • T-cell Biology

Background:

  • Immuno-oncology and cellular therapies highlight the importance of T-cell biology.
  • Long-term immunity is now a key focus in cancer research, moving beyond infection studies.
  • Memory T-cell formation involves numerous signaling pathways, transcription factors, and metabolic regulators.

Purpose of the Study:

  • To review the current understanding of the signal transducer and activator of transcription-3 (STAT3) pathway's role.
  • To explore STAT3's function in the development of memory T cells.
  • To elucidate STAT3's contribution to antitumor immunity.

Main Methods:

  • Literature review of existing research on STAT3 signaling.
  • Analysis of studies investigating T-cell memory formation.
  • Synthesis of data on the role of STAT3 in cancer immunology.

Main Results:

  • Increasing evidence points to STAT3 signaling as critical for long-term T-cell immunity.
  • STAT3 is implicated in the formation of T cells capable of efficient recall responses.
  • The pathway plays a significant role in establishing protective antitumor immunity.

Conclusions:

  • STAT3 signaling is a key regulator in the generation of memory T cells.
  • Understanding STAT3's role can advance the development of novel cancer immunotherapies.
  • Targeting STAT3 may enhance long-term immunity and improve patient outcomes in cancer treatment.