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Related Experiment Videos

Pulmonary arteriovenous malformations: a critical update.

C M Burke, C Safai, D P Nelson

    The American Review of Respiratory Disease
    |August 1, 1986
    PubMed
    Summary

    Pulmonary arteriovenous malformations (PAVM) are rare, and their natural history is unclear. Definitive treatment, preferably embolotherapy, is recommended for most PAVM patients due to high morbidity and mortality risks.

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    Area of Science:

    • Cardiology
    • Pulmonary Medicine
    • Vascular Surgery

    Background:

    • Pulmonary arteriovenous malformations (PAVM) are rare vascular anomalies with incompletely understood natural history.
    • Despite being known for 90 years, etiological factors and clinical features require further elucidation.

    Purpose of the Study:

    • To review historical perspectives, pathological classification, and clinical features of PAVM.
    • To outline diagnostic modalities and suggest a logical investigation sequence.
    • To evaluate treatment options and their impact on morbidity and mortality.

    Main Methods:

    • Review of 450 reported cases of PAVM.
    • Analysis of historical data, pathological classifications, and clinical presentations.
    • Evaluation of diagnostic modalities including pulmonary angiography.
    • Assessment of treatment outcomes for surgical resection and embolic occlusion.

    Main Results:

    • Pulmonary angiography is mandatory before definitive treatment.
    • Untreated PAVM is associated with significant morbidity and mortality.
    • Embolotherapy is the preferred treatment in experienced centers, despite limited long-term data.
    • Surgical resection is an alternative treatment option.

    Conclusions:

    • Definitive treatment for PAVM is generally recommended, except possibly for asymptomatic patients with small lesions and no Osler-Weber-Rendu disease.
    • Embolotherapy is the current treatment of choice, necessitating further long-term follow-up studies.
    • Increased documentation of long-term outcomes in treated and untreated PAVM patients is crucial for improved management.

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