[Pathogenesis and morphologic features of candidal colpitis]

Pathomorphogenesis of candidal colpitis was studied using the murine model with induced oestrus. After intravaginal inoculation, the adherence of pathogen to the mucosal surface of vagina is noted which is followed by its invasion into superficial and deep epithelial layers with the formation of germ tubes and pseudomycelium. The fungal cells are eliminated by the epithelial desquamation and by leukocytes migrating into the epithelium and forming intraepithelial abscesses. The sanation of mucosa is achieved by the sequestration of infected epithelium from the non-infected one. Tissue reactions appear to be in close correlation with the activity of pathogen during all the phases of mycotic process.