Naked-Eye Detection of Morphine by Au@Ag Nanoparticles-Based Colorimetric Chemosensors

In this study, we report a novel and facile colorimetric assay based on silver citrate-coated Au@Ag nanoparticles (Au@AgNPs) as a chemosensor for the naked-eye detection of morphine (MOR). The developed optical sensing approach relied on the aggregation of Au@Ag NPs upon exposure to morphine, which led to an evident color variation from light-yellow to brown. Au@Ag NPs have been prepared by two different protocols, using high- and low-power ultrasonic irradiation. The sonochemical method was essential for the sensing properties of the resulting nanoparticles. This facile sensing method has several advantages including excellent stability, selectivity, prompt detection, and cost-effectiveness.