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[Modern strategies of antithrombotic therapy in patients with multifocal atherosclerosis]

S S Kucherenko1,2, T M Alekseeva2

  • 1Sokolov North-Western District Scientific and Clinical Center, St. Petersburg, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|March 10, 2022
PubMed

Insights

Selecting antithrombotic therapy is crucial for multifocal atherosclerosis patients, especially those with cerebrovascular disease. Combination therapy with aspirin and rivaroxaban shows promise in preventing noncardioembolic stroke.

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Medicine

Background:

  • Multifocal atherosclerosis poses significant risks, with cerebrovascular pathology being a leading cause of mortality and disability.
  • Understanding the etiology, pathogenesis, and pathogenetic subtypes of ischemic stroke is critical for effective management.
  • Antithrombotic therapy plays a vital role in preventing noncardioembolic stroke.

Purpose of the Study:

  • To analyze modern antithrombotic therapy strategies for patients with multifocal atherosclerosis.
  • To evaluate evidence-based medicine data from randomized trials on antithrombotic treatments.
  • To present new findings on combination therapy for stroke prevention.

Main Methods:

  • Review of evidence-based medicine data.
  • Analysis of results from randomized clinical trials.
  • Comparative analysis of clinical trial outcomes.

Main Results:

  • Demonstration of modern antithrombotic therapy strategies based on randomized trials.
  • Analysis of pathogenetic subtypes of ischemic stroke and diagnostic criteria.
  • Highlighting the benefits of combination therapy with acetylsalicylic acid (100 mg/day) and rivaroxaban (2.5 mg twice daily) as shown in the COMPASS study.

Conclusions:

  • Antithrombotic therapy selection is key in managing multifocal atherosclerosis.
  • Combination therapy with low-dose aspirin and rivaroxaban offers significant benefits in preventing noncardioembolic stroke.
  • Evidence supports modern antithrombotic strategies, including combination therapy, for improved patient outcomes.

Keywords:
antithrombotic therapymultifocal atherosclerosisprevention of noncardioembolic ischemic stroke

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