DEVELOPMENT OF NEW APPROACHES TO THE TREATMENT OF HEMANGIOMAS IN EXPERIMENT

The aim of the study was to determine the endogenous factors regulating angiogenesis and develop new approaches to the treatment of uncontrolled growth of capillaries. The effect of a cell proliferation inhibiting thermostable protein complex (TPC), isolated from adult chicken liver, on an experimental model of Hemangioma (adolescent chicken comb) was studied. It has been proved that thermostable proteins isolated from the liver of adult chicken have the ability to inhibit the growth of adolescent bird comb. In particular, it has been shown that daily TPC injection (200 µg) into the comb of animals of the experimental group for 22 days causes visible changes in the color and size of the comb. To explain the changes in typical skin redness and the comb size, quantitative changes in capillaries in highly vascularized papillary layer of the dermis were assessed using histological assessment. Based on the results we can conclude that, the thermostable protein complex of adult chicken liver has the ability to inhibit capillary growth of adolescent chicken comb.