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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

ASSFN Position Statement on Deep Brain Stimulation for Medication-Refractory Epilepsy.

Abhijeet Gummadavelli¹, Dario J Englot², Jason M Schwalb³

¹Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA.

|March 10, 2022

Summary

Deep brain stimulation (DBS) of the anterior nucleus of the thalamus is a safe and effective surgical option for refractory epilepsy. This neuromodulation technique expands treatment choices for patients ineligible for resective surgery.

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Area of Science:

Neurosurgery
Neurology
Epilepsy Research

Background:

Approximately one-third of epilepsy patients have medication-refractory epilepsy.
There is an underuse of surgical interventions for epilepsy.
Neuromodulation offers alternative surgical options for epilepsy patients.

Purpose of the Study:

To summarize evidence on deep brain stimulation (DBS) for epilepsy.
To provide recommendations for DBS in epilepsy treatment.
To identify future research directions for DBS in epilepsy.

Main Methods:

Consensus position statement based on a review of evidence.
Analysis of randomized and blinded clinical trials.
Recommendations from the American Society of Functional and Stereotactic Neurosurgeons.

Main Results:

Deep brain stimulation (DBS) of the anterior nucleus of the thalamus is FDA-approved.
DBS is a safe and efficacious treatment for refractory focal epilepsy.
High-quality data support DBS for refractory focal-onset seizures.

Conclusions:

DBS of the anterior nucleus of the thalamus is a viable surgical option for refractory focal epilepsy.
Neuromodulation, specifically DBS, expands surgical possibilities for epilepsy patients.
Further research is needed to define optimal indications and patient populations for DBS in epilepsy.