Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparing Guided Surgical Endodontics Using Static Guidance, Dynamic Navigation, and Augmented Reality: A Systematic Review and Meta-analysis.

European journal of dentistry·2026

Same author

Artificial Intelligence in Dental Education: Overview of Teaching, Assessment and Academic Performance Prediction.

International dental journal·2026

Same author

Developing a competency framework for artificial intelligence in undergraduate dental education.

Frontiers in dental medicine·2026

Same author

Federated Learning in Endodontics: A Framework for Privacy-Preserving Multicentre Artificial Intelligence.

International dental journal·2026

Same author

Reimagining Dental Education: Integrating Digital Technologies for a Global, Digitally Native Generation-A Perspective.

European journal of dentistry·2026

Same author

Correction: Quantum-inspired fused explainable deep learning framework for early enamel caries classification in intraoral photographs.

Odontology·2026

Search research articles

Related Experiment Video

Updated: Sep 30, 2025

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Published on: November 16, 2018

Specific microRNAs Regulate Dental Pulp Stem Cell Behavior.

Promphakkon Kulthanaamondhita¹, Chatvadee Kornsuthisopon¹, Suphalak Photichailert¹

¹Dental Stem Cell Biology Research Unit and Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Journal of Endodontics

|March 10, 2022

Summary

MicroRNAs (miRNAs) regulate dental pulp stem cell (DPSC) behavior, influencing their stemness, differentiation, and proliferation. Understanding these miRNA functions is key for developing new regenerative dental therapies.

Keywords:

Dental pulp stem cells differentiation inflammation microRNAs proliferation

More Related Videos

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Published on: July 8, 2021

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

Related Experiment Videos

Last Updated: Sep 30, 2025

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Published on: November 16, 2018

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Published on: July 8, 2021

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

Area of Science:

Biomedical Science
Molecular Biology
Stem Cell Biology

Background:

MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression.
miRNAs play critical roles in physiological and pathological processes.
Dental pulp stem cells (DPSCs) are crucial for dental tissue regeneration.

Purpose of the Study:

To systematically review the functions of miRNAs in regulating dental pulp stem cell (DPSC) behavior.
To explore the impact of miRNAs on DPSC stemness, proliferation, and differentiation.

Main Methods:

Systematic literature search of PubMed, SCOPUS, and ISI Web of Science databases.
Inclusion of full-length, peer-reviewed English manuscripts.
Review conducted by two independent researchers.

Main Results:

miRNAs modulate stemness and differentiation in mesenchymal stem cells, including DPSCs.
DPSC miRNA expression profiles differ from other cell types.
miRNAs regulate key proteins affecting DPSC proliferation, differentiation, and inflammatory processes.

Conclusions:

miRNAs significantly regulate DPSC functions.
Understanding miRNA roles is vital for novel therapeutics in regenerative dentistry.
miRNA technology holds revolutionary potential for regenerative endodontics.