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Cyclin-dependent kinases in DNA damage response

Mateusz Kciuk1, Adrianna Gielecińska2, Somdutt Mujwar3

  • 1Department of Molecular Biotechnology and Genetics, Laboratory of Cytogenetics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland; University of Lodz, Doctoral School of Exact and Natural Sciences, Banacha Street 12/16, 90-237 Lodz, Poland.

Biochimica Et Biophysica Acta. Reviews on Cancer
|March 10, 2022
PubMed

Insights

Cyclin-dependent kinases (CDKs) are crucial for DNA damage response and repair. This review explores how CDKs modulate key repair pathways, ensuring genomic integrity after DNA damage.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cyclin-dependent kinases (CDKs) regulate fundamental cellular processes including transcription and cell-cycle progression.
  • Emerging research highlights the significant role of CDKs in the DNA damage response (DDR).

Purpose of the Study:

  • To review the impact of CDK family members on DNA damage response (DDR) pathways.
  • To discuss the modulatory role of CDKs in DNA repair mechanisms, specifically double-strand break repair (DSBR).

Main Methods:

  • Literature review of studies investigating CDK involvement in DDR.
  • Analysis of CDK influence on DNA repair enzymes and pathways, including homologous recombination (HR) and non-homologous end-joining (NHEJ).

Main Results:

  • CDKs significantly affect both the signaling and repair phases of the DDR.
  • CDKs modulate key enzymes involved in homologous recombination (HR) and non-homologous end-joining (NHEJ) for double-strand break repair (DSBR).

Conclusions:

  • CDKs are integral to maintaining genomic integrity following DNA damage.
  • Understanding CDK functions in DDR is crucial for comprehending cell division fidelity and genome stability.
Keywords:
Cell-cycle checkpointCyclin-dependent kinase (CDK)DNA damage response (DDR)DNA repair

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