Levels and effects of antidepressant drugs to aquatic organisms

The use of antidepressants has been increasing globally, resulting in their presence in the aquatic environment, mainly by municipal wastewaters. This fact has aroused concern in the scientific community since these biologically active compounds can affect non-target organisms that have physiological systems regulated by these pharmaceuticals. However, the current knowledge on the toxicological effects of antidepressants on aquatic ecosystems is limited. Considering the increasing consumption pattern, quantification studies and toxicity studies, the present work aimed to review the available literature, published in the last seven years, addressing levels of antidepressants and their metabolites in rivers, surface waters, tap water, and wastewater treatment plants, as well, the effects reported in fish and invertebrates. Overall, the available laboratory studies showed that antidepressants can act at different levels of biological organisation, with detrimental effects at the individual level (e.g., survival, growth, and morphology, behaviour, and reproduction). However, the effects of prolonged exposures to environmentally relevant concentrations of these substances, a more realistic scenario, are unknown. Based on short-term studies, the long-term effects of pharmaceuticals at environmentally relevant concentrations (alone and in the presence of other environmental contaminants) should be studied.