Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complementation Tests00:49

Complementation Tests

5.4K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
5.4K
Complement System01:27

Complement System

3.0K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
3.0K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

858
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
858
Cross-reactivity00:42

Cross-reactivity

31.6K
Overview
31.6K
Humoral Immune Responses01:36

Humoral Immune Responses

77.5K
Overview
77.5K
Hypersensitivities01:30

Hypersensitivities

1.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C3 glomerulopathy associated with anti-factor H autoantibodies in a child with inflammatory bowel disease.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Functional Characterization of a Novel Intronic Complement Factor I Variant in Factor I Deficiency and Atypical Hemolytic Uremic Syndrome.

Kidney international reports·2026
Same author

Laboratory Monitoring of Complement Activation in Gene Therapy: Analytical Pitfalls and Clinical Interpretation.

Seminars in thrombosis and hemostasis·2026
Same author

[Thrombotic microangiopathy caused by vitamin B12 and folate deficiency (pseudo-TMA)].

Orvosi hetilap·2026
Same author

Antibody Deficiency in Xeroderma Pigmentosum.

Journal of clinical immunology·2026
Same author

Crovalimab Rescue Therapy in a Case With Genetic Complement Mediated Thrombotic Microangiopathy.

Kidney medicine·2026
Same journal

Eosinophilic Gastrointestinal Disorders Prevention: Insights From Early Life Influences and Atopic Conditions.

The journal of allergy and clinical immunology. In practice·2026
Same journal

Prediction model for children with anaphylaxis who may not require emergency department care: a multicenter retrospective cohort study.

The journal of allergy and clinical immunology. In practice·2026
Same journal

Quality and Safety Intervention: Improving Care of Patients Undergoing B-cell Targeted Therapies.

The journal of allergy and clinical immunology. In practice·2026
Same journal

Screening for Eosinophilic Esophagitis in the Pediatric Asthma Clinic Leads to Increased Diagnosis and Identifies a High Prevalence of Disease.

The journal of allergy and clinical immunology. In practice·2026
Same journal

Development and validation of clinical scoring system to estimate mucus plug presence in asthma.

The journal of allergy and clinical immunology. In practice·2026
Same journal

Timing of High-Risk Asthma Specialist Enrollment and Severe Asthma Exacerbations in Children.

The journal of allergy and clinical immunology. In practice·2026
See all related articles

Related Experiment Video

Updated: Sep 30, 2025

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.3K

Complement Genetics for the Practicing Allergist Immunologist: Focus on Complement Deficiencies.

Ágnes Szilágyi1, Dorottya Csuka1, Christoph B Geier2

  • 1Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.

The Journal of Allergy and Clinical Immunology. in Practice
|March 10, 2022
PubMed
Summary
This summary is machine-generated.

Complement deficiencies are increasingly recognized due to advanced testing and clinical awareness. Identifying genetic causes and functional impacts is crucial for accurate diagnosis and management of these rare conditions.

Keywords:
Anti-C1q autoantibodyBacterial infectionsC2C8Complement deficiencyFactor IMannose-binding lectinSystemic autoimmunity

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K
Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
09:27

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways

Published on: June 24, 2016

17.8K

Related Experiment Videos

Last Updated: Sep 30, 2025

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.3K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K
Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
09:27

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways

Published on: June 24, 2016

17.8K

Area of Science:

  • Immunology
  • Genetics

Background:

  • Complement deficiencies were historically considered rare, but this perception is evolving.
  • Increased clinical awareness and improved diagnostic testing methods contribute to higher recognition rates.

Purpose of the Study:

  • To present four cases of complement deficiencies with varied causes.
  • To provide a guide for identifying the genetic basis of complement deficiency using laboratory test results.

Main Methods:

  • Review of clinical cases with complement deficiencies.
  • Application of various genetic sequencing technologies (Sanger, targeted panels, WES/WGS).
  • Functional characterization of genetic variations and family studies.

Main Results:

  • Four diverse cases of complement deficiencies were analyzed.
  • Genetic sequencing facilitated the identification of underlying genetic causes.
  • Functional studies and family investigations were essential for precise diagnosis.

Conclusions:

  • Complement deficiencies are more common than previously thought.
  • A combination of laboratory testing, genetic sequencing, and functional analysis is key for diagnosing complement deficiencies.
  • Accurate diagnosis is vital for appropriate patient management.