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Updated: Sep 30, 2025

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Care for Transgender Young People
Damian Krebs1, Rebecca M Harris2,3, Alyssa Steinbaum4
1Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
This review covers gender-affirming care for transgender and gender-diverse (TGD) youth, including medical interventions like hormone therapy. It highlights known and unknown risks, emphasizing personalized treatment plans for TGD individuals.
Area of Science:
- Pediatric Endocrinology
- Adolescent Medicine
- Gender-Affirming Care
Background:
- Clinicians frequently encounter transgender and gender-diverse (TGD) youth.
- Affirming care is crucial for TGD individuals, encompassing social and medical interventions.
- The transition journey is unique for each TGD patient.
Purpose of the Study:
- To provide an overview of gender-affirming care for TGD young people.
- To summarize current knowledge on the outcomes of medical gender transition therapies.
- To inform clinicians about the implications of these therapies for patient health.
Main Methods:
- Literature review on gender-affirming care for TGD youth.
- Summary of existing research on medical interventions and their outcomes.
- Discussion of risks and benefits associated with therapies.
Main Results:
- Gender-affirming care may include social transition and medical interventions like hormone therapy.
- Medical therapies can impact growth, bone health, cardiovascular health, and fertility.
- Long-term outcomes of these therapies are not yet fully understood.
Conclusions:
- Clinicians must be aware of affirming practices for TGD youth.
- Informed consent regarding known and unknown risks is essential.
- Collaborative treatment planning aligned with individual goals is paramount for TGD individuals.
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