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Recurrent Urinary Tract Infection Incidence Rates Decrease in Women With Cystitis Cystica After Treatment With
Kimberley Chiu1, Fan Zhang2, Siobhan Sutcliffe3
1From the Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology.
Female Pelvic Medicine & Reconstructive Surgery
|March 10, 2022
Summary
d-Mannose effectively reduces recurrent urinary tract infections (rUTIs) in postmenopausal women, including those with cystitis cystica (CC) lesions. This nonantibiotic prophylaxis significantly lowers UTI incidence in both CC and non-CC groups.
Area of Science:
- Urology
- Gynecology
- Pharmacology
Background:
- Recurrent urinary tract infections (rUTIs) are common in postmenopausal women.
- Cystitis cystica (CC) lesions may be associated with a higher incidence of rUTI.
- d-Mannose is a nonantibiotic agent explored for rUTI prophylaxis.
Purpose of the Study:
- To determine if CC lesions are linked to increased UTI rates.
- To evaluate the efficacy of d-mannose in reducing UTI incidence in women with CC.
Main Methods:
- Retrospective cohort study of 27 patients with rUTI undergoing cystoscopy.
- Comparison of UTI incidence rates before and after d-mannose prophylaxis.
- Analysis of UTI rates in patients with and without CC lesions.
Main Results:
- Patients with CC had a higher baseline UTI incidence rate (4.69/year) compared to those without CC (2.93/year).
- d-Mannose significantly decreased UTI incidence in patients with CC (2.23/year reduction, P=0.0028).
- Similar significant reductions were observed in patients without CC (1.64/year reduction, P=0.0007).
Conclusions:
- Women with rUTI and CC experience more frequent infections.
- d-Mannose prophylaxis led to a significant reduction in UTI episodes for both CC and non-CC groups.
- d-Mannose is a viable option for preventing rUTI in women, including those with CC.
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